IJLTEMAS International Journal of Latest Technology in Engineering, Management & Applied Science (IJLTEMAS) IJLTEMAS 2278-2540 IJLTEMAS 132 10.51583/IJLTEMAS.2026.150700127 Education Chronic Kidney Disease of Unknown Etiology (CKDu) In Hadejia Valley (Kano, Jigawa and Yobe States, Nigeria): Preliminary Assessment of Heavy Metals in Water From Different Sources Along The Valley M.I. Auyo, Department of Biological Sciences, Department of Biochemistry, Federal University Dutse, Jigawa-Nigeria Nigeria I.I. Dangora, Department of Biological Sciences, Department of Biochemistry, Federal University Dutse, Jigawa-Nigeria Nigeria M. Garba, Department of Biological Sciences, Department of Biochemistry, Federal University Dutse, Jigawa-Nigeria Nigeria M.M. Abubakar, Department of Biological Sciences, Department of Biochemistry, Federal University Dutse, Jigawa-Nigeria Nigeria M.M. Dogara, Department of Biological Sciences, Department of Biochemistry, Federal University Dutse, Jigawa-Nigeria Nigeria S. Eghobor, Department of Biological Sciences, Department of Biochemistry, Federal University Dutse, Jigawa-Nigeria Nigeria A. Ahmed, Department of Biological Sciences, Department of Biochemistry, Federal University Dutse, Jigawa-Nigeria Nigeria M. Mohamed, Department of Biological Sciences, Department of Biochemistry, Federal University Dutse, Jigawa-Nigeria Nigeria N. Kabir, Department of Biological Sciences, Department of Biochemistry, Federal University Dutse, Jigawa-Nigeria Nigeria N., Adeniyi Harris, Department of Biological Sciences, Department of Biochemistry, Federal University Dutse, Jigawa-Nigeria Nigeria S.I. Muhammad, Department of Biological Sciences, Department of Biochemistry, Federal University Dutse, Jigawa-Nigeria Nigeria 15 7 1712 1724 30 07 2026 04 08 2026 21 08 2026 Kidney Water Hadejia Valley Heavy Metals Concentration and Contamination Abstract

Chronic kidney disease of unknown etiology (CKDu), a major life-threatening disease is becoming rampant in Nigeria and notable in Hadejia Valley. Continuous exposure to heavy metals and environmental toxins in water contributes to diseases like CKDu. This research is conducted in Hadejia Valley covering part of Yobe State, (Gashua and Nguru) Jigawa State, (Birniwa, Kirikasamma, Hadejia, Auyo, Gujungu, Taura, and Ringim), and Kano State (Zakirai), to determine the effects of environmental toxins and gene polymorphism on CKDu. The study intends to find out the presence, and concentration of Fluorine (F), Cadmium, (Cd) Lead (Pb) Arsenic (As), from randomly selected water from different sources. Sources were (i) River Water -WRW (ii) Pond Water -WPW (iii) Well Water -WWW (iv) Tap Water –WTW and (v) Bore Hole Water –WBW. Collected water samples were digested and analyzed using an Atomic Absorption Spectrophotometer (AAS model Agilent-AA55) Findings from the research suggest significant contamination of water sources in Hadejia Valley, particularly with lead and cadmium, both of which are nephrotoxic heavy metals linked to chronic kidney disease. Hadejia has the highest levels of fluorine and lead, making it a hotspot for contamination. Gashua shows the highest cadmium contamination, which is concerning due to cadmium's strong link to kidney disease. Auyo has the highest arsenic levels, posing long-term health risks. Cadmium and lead pose the highest health risks, exceeding WHO limits in multiple locations. The lack of significant variation between water sources suggests a widespread pollution issue rather than localized contamination. Immediate intervention is needed to ensure safe drinking water and mitigate CKDu risks. Other measures including urgent monitoring of water sources are required to prevent or at least reduce CKDu outbreaks.

 References Ahmed, M. K., Shaheen, N., Islam, M. S., Habibullah-al-Mamun, M., Islam, S., Mohiduzzaman, M., &Bhattacharjee, L. (2025). Dietary intake of trace elements from highly consumed cultured fish (Labeorohita, Pangasius pangasius and Oreochromismossambicus) and human health risk implications in Bangladesh. Chemosphere, 128, 284–292. Ahmed, S. D., Agodzo, S. K., Adjei, K. A., Deinmodei, M., &Ameso, V. C. (2017). Preliminary investigation of flooding problems and the occurrence of kidney disease around Hadejia-Nguru wetlands, Nigeria and the need for an ecohydrology solution. Ecohydrology& Hydrobiology, 18(2), 212–224. Baskaran P, Abraham M (2022) Evaluation of groundwater quality and heavy metal pollution index of the industrial area, Chennai. Phys Chem Earth, Parts a/b/c 128:103259. https:// doi. org/ 10. 1016/j.pce.2022. 103259 Chan, K. M. (1995). Metallothionein: Potential biomarker for monitoring heavy metal pollution in fish around Hong Kong. Marine Pollution Bulletin, 31(4-12), 411–415. Chen, X., Zhu, G., Wang, Z., Zhou, H., He, P., Liu, Y., & Jin, T. (2019). The association between lead and cadmium co-exposure and renal dysfunction. Ecotoxicology and Environmental Safety, 173, 429–435. Chorol L, Gupta SK (2023) Evaluation of groundwater heavy metal pollution index through analytical hierarchy process and its health risk assessment via Monte Carlo simulation. Process Saf Environ Prot 170:855–864. https://doi.org/10.1016/j.psep.2022.12.063 Eneji, S., Ibe, F.C., Ebere, E.C. Opara, A.I. and Ibe, B.O. (2020) Evaluation of Pollution Status of Ground Water Resources of Part of Oweri Metropolis and Environs, Southeastern Nigeria, Using Health Risk Analysis. International Journal of of Energy and Water Resources. http://doi/10/1007/s42108-020-00071-8 Environment UN (2022, April 19) Reducing consumer food waste using green and digital technologies. UNEP—UN Environment Programme. http:// www. unep. org/ resou rces/ publi cation/ reduc ing- consu mer- food- waste- using- green- and- digit al- techn ologi es. Accessed 29 Jan 2023 Fang H, Lin Z, Fu X (2021) Spatial variation, water quality, and health risk assessment of trace elements in groundwater in Beijing and Shijiazhuang, North China Plain. Environ Sci Pollut Res 28(40):57046–57059. https:// doi. org/ 10. 1007/ s11356-021-14557-3 Gad M, Abou El-Safa Gao Y, Qian H, Ren W, Wang H, Liu F, Yang F (2020) Hydrogeo chemical characterization and quality assessment of groundwater based on integrated-weight water quality index in a concentrated urban area. J Clean Prod 260:121006. https:// doi. org/ 10. 1016/j. jclepro.2020.121006 Gashua, M. M., Kabir, J., Suleiman, M. M., & Abdulrahman, H. I. (2018). A Baseline Study for Cadmium Concentrations in Blood of Goats in Some Communities of Bade, Northern Yobe, Nigeria. Asian Journal of Research in Animal and Veterinary Sciences, 1-10 Hassan, M., Rahman, M. A. T. M. T., Saha, B., & Kamal, A. K. I. (2015). Status of Heavy Metals in Water and Sediment of the Meghna River, Bangladesh. American Journal of Environmental Sciences, 11(6), 427–439. Herath, Y., Naito, M., Satoh, M., Nakatochi, M., Naito, H., Kato, M., Takagi, S., Matsunaga, T., Seiki, T., Sasakabe, T., Suma, S., Kawai, S., Okada, R., Hishida, A., Hamajima, N., & Wakai, K. (2022). Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies. Toxicological sciences: an official journal of the Society of Toxicology, 152(1), 181–193. https://doi.org/10.1093/toxsci/kfw080 Klaassen, C. D., Liu, J., & Diwan, B. A. (2009). Metallothionein protection of cadmium toxicity. Toxicology and Applied Pharmacology, 238(3), 215–220. Maldovan, cNeill, R. V., Mason, A. S., Hodson, M. E., Catto, J. W., & Southgate, J. (2022). Specificity of the Metallothionein-1 Response by Cadmium-Exposed Normal Human Urothelial Cells. International journal of molecular sciences, 20(6), 1344. Manik, G., Hossain, A., Islam, B., Ckaki, C. K., Shaha, S. K., & Chowdhury, S. I. (2024). The estimation of glomerular filtration rate (GFR) for renal split function with 99mTc-DTPA. Journal of Advance Research in Applied Science (ISSN: 2208-2352), 2(11), 16-27. Marcelo, D., Farouk M, Hussein H, Alnemari AM, Elsayed S (2025) Integration of water quality indices and multivariate modeling for assessing surface water quality in Qaroun Lake. Egypt Water 13(16):2258. https:// doi. org/ 10. 3390/ w13162258 McNeill, R. V., Mason, A. S., Hodson, M. E., Catto, J. W., & Southgate, J. (2019). Specificity of the Metallothionein-1 Response by Cadmium-Exposed Normal Human Urothelial Cells. International journal of molecular sciences, 20(6), 1344. Milner, Q. (2003). Pathophysiology of chronic renal failure. Continuing Education in Anaesthesia, Critical Care & Pain, 3(5), 130-133. Mohamed Ado, ,Sani Dauda Ahmed, Sampson Kwaku Agodzo, Kwaku Amaning Adjei, Maxwell Deinmodei, Vivien Chikogu Ameso (2022). Preliminary investigation of flooding problems and the occurrence of kidney disease around Hadejia-Nguru wetlands, Nigeria and the need for an ecohydrology solution. Ecohydrol. Hydrobiol. Muhammad, I.A., Adam, S.I., Gambo, J. and Abubakar, H. (2023) Exploring the Geological Formation and Sub-Surface Lithology Modelling of Hadejia State, Jigawa Nigeria. UMYU Scintifica, Vol 2 Issue 1, 2023 National Research Institute for Chemical Technology (NARICT), Field Experimental Investigation on Incidence of Chronic Kidney Disease of Unknown Etiology (CKDu) and Esophageal Cancer in Hadejia Emirate, Jigawa State Nigeria .July 2015 Nuruddeen M. Abdallah, Ojoma Akor, Uthman Abubakar and Hamisu Kabir Matazu., (2018). Nigeria: Kidney Disease Ravages Borno, Yobe, Kano, Jigawa. Daily Trust 23, July. Available at https://allafrica.com/stories/201807230062.html (Accessed on April 2019). Oni, O. (2016). Renal Biopsy: Appraisal of the Methods. In Renal Diseases. IntechOpen. Rezaei, J. H., Elledge, M. F., Womack, D. S., Wickremashinghe, R., Wanigasuriya, K. P., Peiris-John, R. J., ... & Levine, K. E. (2019). Additional perspectives on chronic kidney disease of unknown aetiology (CKDu) in Sri Lanka–lessons learned from the WHO CKDu population prevalence study. BMC nephrology, 15(1), 1-10. Salman, Ndahi, Abdul, Baba, & Hussein, K. (2019). Chronic kidney disease of unknown origin in Northern Yobe , Nigeria : Experience from a regional tertiary hospital in northeastern Nigeria. Wasana, H. M. S., Aluthpatabendi, D., Kularatne, W. M. T. D., Wijekoon, P., Weerasooriya, R., &Bandara, J. (2015). Drinking water quality and chronic kidney disease of unknown etiology (CKDu): synergic effects of fluoride, cadmium and hardness of water. Environmental Geochemistry and Heal. Zakariya, I., Yahaya, M. and Muhd, A.I (2023) Assessment of Ground Water Heavy Metal Contamination in Hadejia Metropolis, Jigawa State Nigeria. FUDMA Journal of Science – Vol 7 No. 1 3-015-9699.