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Predictors of COVID-19 Mortality: A Stratified 3 by 3 Factorial
Correlation Analysis
Wilfred Omwansa Arori
1
1
Maseno University, School of Mathematics Statistics and Actuarial Science
DOI: https://doi.org/10.51583/IJLTEMAS.2026.150500133
Received: 30 April 2026; Accepted: 15 May 2026; Published: 08 June 2026
ABSTRACT
In this paper the strength of association of some factors with COVID-19 mortality across countries is examined.
This is essential for future pandemic preparedness. In this study, a 3 × 3 factorial design where 36 countries were
stratified by GDP per capita and population density was used. Secondary data were sourced from the World
Bank, United Nations, and Our World in Data repositories. A parsimonious linear regression model with four
predictors: positivity rate, vaccination coverage, log (GDP per capita), and median age was fitted. Bootstrapping
provided 95% confidence intervals. Low-GDP countries had higher positivity rates (10.2% vs. 3.0%) but lower
reported deaths (167 vs. 1,186 per million) than high-GDP countries. The model explained 89.2% of variance
(adjusted R² = 0.878, p < 0.001). Positivity rate was the strongest predictor of mortality (β = 10.51, p < 0.001),
followed by GDP per capita (β = 1.39, p < 0.001). The positivity-deaths correlation was strongest in high-GDP
countries (r = 0.898, p < 0.001) compared to low-GDP countries (r = 0.597, p = 0.019), suggesting that
differential death reporting attenuates associations in low-resource settings. These findings suggest positivity
rate as a high value predictor of COVID-19 mortality. Maintaining low positivity rates through accessible testing
should guide future pandemic surveillance.
Keywords: COVID -19, positivity rate, testing, vaccination, GDP
INTRODUCTION
The Coronavirus Disease 2019 (COVID-19) pandemic emerged as a global health crisis in late 2019, triggering
varied public health responses across the world (World Health Organization, 2020). As of December 2022, over
6.9 million confirmed deaths had been reported to the World Health Organization, though excess mortality
estimates suggest substantially higher figures (Msemburi et al., 2023). Understanding the factors that correlated
with mortality across different countries and settings is essential for future pandemic preparedness, as the
variation in outcomes revealed critical challenges in global health systems (Klement & Walach, 2022).
Socioeconomic Determinants of COVID-19 Mortality
The relationship between economic indicators and COVID-19 outcomes has been extensively studied. A
systematic review that included 31 studies following Preferred Reporting Items for Systematic Reviews and
Meta-Analyses (PRISMA) guidelines found that both Gross Domestic Product (GDP) per capita and income
inequality (measured by the Gini coefficient) influenced COVID-19 mortality rates significantly across countries
(Abbasi et al., 2025). Interestingly, a paradoxical relationship was identified: while higher GDP provided some
protective benefits, it did not completely shield countries from high mortality, particularly when considering
economic activity and population demographics. This paradox has been attributed to more complete death
reporting in wealthier nations, older population structures, and earlier epidemic waves before vaccines became
available.
A global analysis conducted in 95 countries classified by gross national income per capita revealed that high-
income and upper-middle-income countries experienced significantly higher reported mortality rates
(233.0±138.7 and 168.9±141.3 per 100,000 population, respectively) compared to lower-middle-income
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(50.1±69.1) and low-income (6.3±5.5) countries (Kanokudom et al., 2025). Within high-income countries, GDP
per capita demonstrated a strong negative correlation with mortality (Spearman's r = -0.562, p < 0.001),
suggesting that among wealthier nations, greater economic resources were associated with lower death rates.
However, among lower-middle-income countries, a strong positive correlation was observed (Spearman's r =
0.629, p = 0.002), indicating a more complex relationship that warrants further investigation.
Testing, Positivity Rate, and Surveillance Capacity
The relationship between testing capacity and mortality outcomes has also been studied. The World Health
Organization recommended that positivity rates remain below 5% for 14 days before reopening, as lower
positivity rates indicated adequate surveillance coverage (World Health Organization, 2020). It was found that
testing intensity varied dramatically across income groups, with high-income countries achieving mean
vaccination rates of 76.7% compared to only 27.4% in low-income countries (Kanokudom et al., 2025).
Critically, a strong negative correlation between vaccination coverage and mortality was observed in high-
income countries (Spearman's r = -0.551, p < 0.001), supporting widespread vaccination in reducing mortality.
No such correlation was found in lower-income groups, suggesting that other factors such as testing capacity,
healthcare quality, and death reporting completeness may confound the observed associations.
In a population-based prospective cohort study conducted in the Greater Toronto Area, testing, diagnosis, and
mortality across long-term care homes, shelters, and the general population were compared (Wang et al., 2020).
It was found that residents of long-term care homes were 2.4 times more likely to test positive and 1.4 times
more likely to die after COVID-19 diagnosis than the general population, after adjusting for age and sex. The
diagnosed cases per capita were 64-fold higher among long-term care residents, highlighting how congregate
settings and testing access disparities dramatically affect observed outcomes.
Vaccination Impact on Mortality
The protective effect of vaccination against severe COVID-19 outcomes has been highlighted in a number of
ecological studies. Hospital lethality from Severe Acute Respiratory Illness (SARI) caused by COVID-19 among
older adults in Brazil was examined between 2020 and 2023 (Stocki et al., 2026). It was found that before
vaccination in 2020, lethality was 47.2%; following the start of immunization prioritizing older adults in January
2021, lethality dropped to 35.6%, and by 2022-2023, with expanded vaccine schedules and booster doses,
lethality stabilized between 24% and 26%. Vaccination coverage with complete primary series reached 87% of
older adults in 2021, increasing to over 95% in 2022. It was concluded that COVID-19 vaccination significantly
reduced lethality from SARI, with an inverse association between vaccination coverage and hospital lethality
observed across the study period.
Considering Brazil's age-based vaccination strategy, during the first year of vaccination (January to December
2021), 266 million doses were administered. This was 91% first-dose coverage. Mortality rates among adults
aged 70 years and older decreased by 52% (rate ratio 0.48, 95% CI 0.43-0.53) within six months. Thus the
vaccination strategy prevented an estimated 59,618 deaths, of which 53,088 (89%) were among those aged 70
years and older (Aguilar et al., 2024). However, the strategy did not prevent 54,797 deaths among younger age
groups, corresponding to 1.6 million potential years of life lost, highlighting the challenge of balancing vaccine
supply constraints with equitable distribution.
Age as a Predictor of Severity
The strong association between age and COVID-19 mortality is well-established in the literature. A systematic
review of prognostic models for COVID-19 severity was conducted, identifying 314 eligible articles from more
than 40 countries, with 152 studies presenting mortality outcomes (Buttia et al., 2023). The sample sizes varied
from 11 to over 7.7 million participants, with mean ages ranging from 18 to 93 years. The review identified 353
prognostic models, with area under the curve (AUC) values ranging from 0.44 to 0.99, though 99.4% of studies
were reported to be at high risk of bias due to methodological concerns, including handling of missing data,
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failure to address overfitting, and heterogeneous definitions of outcomes. Despite these limitations, age
consistently emerged as a key predictor across multiple models.
A systematic review of COVID-19 prognostic scores was performed, identifying 242 scores for mortality
(n=109), severity (n=116), hospitalization (n=14), and long-term sequelae (n=3) (Appel et al., 2024). Most scores
were developed using retrospective (75.2%) or single-center (57.1%) cohorts, with predictor analysis revealing
the primary use of laboratory data and sociodemographic information. After in-depth assessment using the
Prediction model Risk Of Bias ASsessment Tool (PROBAST), only five scores ensured low risk of bias, and
based on the number and heterogeneity of validation studies, only the 4C Mortality Score could be recommended
for clinical application. It was concluded that the application and translation of most existing COVID-19
prognostic scores appear unreliable. Standardized predictor selection was advised in order to improve
generalizability for future pandemics.
Population Density and Transmission Dynamics
The relationship between population density and COVID-19 mortality has yielded mixed findings. With
Singapore, there was no significant correlation between mortality rates and population density across any income
group (p 0.05). it was the most crowded country in the analysis (8,270 persons/km²). Low mortality was
achieved through effective public health responses (Kanokudom et al., 2025). This suggests that governance,
healthcare capacity, and testing infrastructure may be more important determinants of outcomes than population
density alone. The variability in findings across studies suggests the complex mix between demographic factors,
policy responses, and healthcare system capacity.
Gaps in the Literature
Despite vast ecological research on COVID-19 mortality determinants, a number of important gaps remain. First,
no study has systematically stratified countries by both GDP per capita and population density in a factorial
design to examine effect modification. Most existing analyses treat these as continuous variables or include them
as controls rather than explicit stratification factors. Second, while testing intensity has been studied, the specific
role of positivity rate (the percentage of tests returning positive) as a direct measure of community transmission
intensity has received limited attention as a separate construct from testing volume. Third, the interaction
between positivity rate and vaccination coverage has not been systematically examined in cross-country
analyses. Fourth, median age is often included as a covariate but rarely examined for effect modification across
economic strata. Fifth, few studies have employed machine learning methods such as SHAP (SHapley Additive
exPlanations) for interpretable feature importance ranking in this context.
The Present Study
The present study addresses these gaps using a stratified sample of 36 countries representing all combinations
of GDP per capita (low, medium, high) and population density (low, medium, high) in a 3 × 3 factorial design.
This approach ensures representation across economic development levels and population dispersion patterns,
reducing confounding by these two major structural factors. A specific focus is placed on positivity rate as the
primary metric of transmission intensity. It is hypothesized that positivity rate would show the strongest
correlation with cumulative COVID-19 deaths per million, independent of testing volume, vaccination coverage,
and demographic factors. Secondary hypotheses examine the indirect effects of GDP through testing capacity
and vaccination coverage, effect modification by GDP stratum, and the moderating role of vaccination on the
positivity-death relationship.
METHODS
Study Design
This was a cross-sectional ecological study of 36 countries, selected using a 3 × 3 factorial design stratified by
GDP per capita (low, medium, high) and population density (low, medium, high). The design yielded nine strata
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with four countries per stratum. This stratification approach ensured representation across economic
development levels and population dispersion patterns, reducing confounding by these two major structural
factors.
Country Selection
Countries were eligible for inclusion if they had (a) population greater than one million, (b) reliable COVID-19
death reporting through December 2022 as assessed by Our World in Data completeness scores, (c) available
testing and vaccination data, and (d) published population density estimates. From each of the nine strata, four
countries were randomly selected from the eligible candidate pool. If a selected country had incomplete data
(>20% missing), it was replaced by another random selection from the same stratum. The final sample consisted
of 36 countries (see Supplementary Table 1 at the appendix).
Measures
GDP per capita (2019 US dollars) was obtained from the World Bank World Development Indicators
(indicator NY.GDP.PCAP.CD), and values were log₁₀ transformed for regression analysis. Population density
(persons per square kilometer) was obtained from the World Bank (indicator EN.POP.DNST), defined as
midyear population divided by land area, with values transformed as log₁₀ (x + 1). Median age (years, 2020
estimate) was obtained from the United Nations Population Division, World Population Prospects 2024
Revision. Testing intensity was measured as cumulative COVID-19 tests per 100,000 population as of December
2022, obtained from Our World in Data, with values log₁₀ transformed. Positivity rate was defined as the peak
7-day rolling average of positive tests divided by total tests, expressed as a percentage, obtained from Our World
in Data, and transformed using the arcsine-square root transformation (arcsin(√(p/100))) to stabilize variance.
Vaccination coverage was defined as the percentage of the total population fully vaccinated against COVID-19
as of December 2022, obtained from Our World in Data. Cumulative deaths were defined as confirmed COVID-
19 deaths per 1,000,000 population as of December 31, 2022, obtained from Our World in Data, with values
log₁₀ (x + 1) transformed to normalize distribution and accommodate zero values.
Statistical Analysis
All analyses were conducted using Python 3.10 with the statsmodels, scikit-learn, and SHAP libraries across
five stages. Descriptive statistics (means and standard deviations) were calculated for all variables overall and
by GDP stratum. Pearson and partial correlations (controlling for median age) were computed between each
predictor and log-transformed deaths per million. Hierarchical multiple linear regression employed five nested
models with dependent variable log₁₀ (Deaths per 1M + 1): Model 1 (base: log Population + log Density); Model
2 (+ log GDP per capita); Model 3 (+ Median age); Model 4 (+ log Tests per 100k + Positivity (arcsine)); and
Model 5 (+ Vaccination coverage). Variance inflation factors (VIF > 10 indicating problematic collinearity)
were assessed (Hair et al., 2010). Based on sample size (n = 36) and VIF results, a parsimonious model with four
predictors (positivity rate, vaccination coverage, log GDP per capita, median age) achieved a 9:1 subject-to-
predictor ratio, adequate for detecting large effects (Cohen, 1992). Bootstrapping (1,000 resamples) provided
bias-corrected 95% confidence intervals. Subgroup analyses examined positivity-deaths correlations across GDP
strata, with Fisher's z-test comparing correlations. All tests were two-tailed with α = 0.05.
RESULTS
Descriptive Characteristics
Table 1 presents descriptive characteristics by GDP stratum. Low-GDP countries (n = 15) had substantially
higher mean positivity rates (10.2%) compared to medium-GDP (7.8%) and high-GDP (3.0%) countries.
Conversely, vaccination coverage was lowest in low-GDP countries (35.4%) and highest in high-GDP countries
(81.9%). Median age ranged from 22.5 years in low-GDP countries to 42.4 years in high-GDP countries.
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Cumulative COVID-19 deaths per million were highest in medium-GDP countries (M = 1,884, SD = 1,257),
followed by high-GDP (M = 1,186, SD = 918) and low-GDP (M = 167, SD = 154) countries.
Table 1: Descriptive Characteristics by GDP Stratum
Variable
Low GDP (n = 15)
Medium GDP (n = 10)
High GDP (n = 11)
GDP per capita (USD)
1,952 ± 681
9,359 ± 1,669
48,034 ± 12,634
Population density (/km²)
281.4 ± 324.9
83.7 ± 52.5
934.0 ± 2,407.7
Median age (years)
22.5 ± 4.9
35.0 ± 4.1
42.4 ± 2.4
Positivity rate (%)
10.2 ± 2.5
7.8 ± 2.8
3.0 ± 1.1
Vaccination coverage (%)
35.4 ± 30.4
69.6 ± 12.5
81.9 ± 5.7
Deaths per 1 million
167 ± 154
1,884 ± 1,257
1,186 ± 918
Note: Values are M ± SD.
Correlation Analysis
Table 2 displays Pearson correlations between each predictor and log-transformed deaths per million. The
strongest correlations were observed for median age (r = 0.734, p < 0.001), testing intensity (r = 0.688, p <
0.001), GDP per capita (r = 0.676, p < 0.001), and vaccination coverage (r = 0.674, p < 0.001). Population density
(r = -0.063, p = 0.713) and population size (r = 0.183, p = 0.285) were not significantly correlated with death
rates.
Table 2: Pearson Correlations with log₁₀ (Deaths per 1 Million)
Variable
r
Positivity rate (%)
-0.201
Vaccination coverage (%)
0.674
Testing intensity (log)
0.688
GDP per capita (log)
0.676
Median age (years)
0.734
Population density (log)
-0.063
Population size (log)
0.183
Note: N = 36. Log-transformed variables are base 10.
Correlation Heat maps
The correlation heat map provides a visual summary of the bivariate relationships among all study variables. In
Panel A, the strongest positive correlations with log deaths per 1M are observed for median age (r = 0.68), testing
intensity (r = 0.76), and GDP per capita (r = 0.84). Notably, testing intensity and GDP per capita show a very
strong positive correlation (r = 0.93), indicating substantial multicollinearity between economic development
and testing capacity. Similarly, GDP per capita is strongly correlated with median age (r = 0.69), reflecting that
wealthier nations tend to have older populations. Population density shows moderate positive correlations with
testing (r = 0.76) and GDP (r = 0.84), while population size exhibits negative correlations with most economic
and health system variables. Panel B presents partial correlations controlling for median age, which helps isolate
unique variance after removing age structure influences. The attenuation of several correlations confirms that
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median age acts as a significant confounder in many relationships, particularly those involving GDP and health
outcomes.
Figure 1: Correlation heat maps of key COVID-19 variables
Panel A (left) shows the full Pearson correlation matrix among all predictors and the outcome variable (log
deaths per 1M). Panel B (right) displays partial correlations controlling for median age, revealing the unique
associations between each pair of variables after accounting for demographic differences. The color scale ranges
from blue (negative correlation) to red (positive correlation), with darker colors indicating stronger associations.
Scatter Plots
Figure 2 shows scatter plots of key relationships among COVID-19 variables. Red dashed lines indicate linear
regression fits. Each panel is described as follows.
Panel A: Positivity Rate vs. Deaths. A weak negative overall correlation was observed (r = -0.201, p = 0.239),
which is biologically counterintuitive. However, low-GDP countries clustered in the upper-left region (high
positivity, low reported deaths), while high-GDP countries clustered in the lower-right region (low positivity,
high reported deaths), reflecting differential death reporting quality. When stratified by GDP, the correlation
became strongly positive within each stratum, particularly for high-GDP countries (r = 0.898, p < 0.001),
demonstrating an ecological fallacy in the aggregate correlation.
Panel B: Vaccination Coverage vs. Deaths. A strong positive correlation was observed (r = 0.674, p < 0.001),
appearing to suggest higher vaccination is associated with higher mortality. Countries with high vaccination
coverage also had high positivity rates (red points), indicating that high community transmission necessitated
aggressive vaccination campaigns. This reverse causality was confirmed by descriptive statistics: high-GDP
countries had both higher vaccination coverage (81.9%) and higher deaths (1,186 per 1M) compared to low-
GDP countries.
Panel C: GDP vs. Deaths. A strong positive correlation was demonstrated (r = 0.676, p < 0.001), indicating
wealthier countries reported higher mortality despite having lower positivity rates. This paradoxical finding was
explained by three factors: older populations in high-GDP countries (median age 42.4 vs. 22.5 years), more
complete death reporting, and earlier epidemic waves before vaccines were available.
Panel D: Testing Intensity vs. Positivity Rate. A strong negative correlation was revealed (r = -0.688, p <
0.001), indicating that higher testing capacity achieves lower positivity rates. High-GDP countries clustered in
the upper-left region (high testing, low positivity), while low-GDP countries clustered in the lower-right region
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(low testing, high positivity). Only high-GDP countries achieved the World Health Organization (WHO)
benchmark of below 5% positivity.
Panel E: Median Age vs. Deaths. The strongest positive correlation among all variables was observed (r =
0.734, p < 0.001), confirming the age gradient in COVID-19 severity. However, in the parsimonious regression
model, median age was not statistically significant (β = 0.022, p = 0.132) when positivity rate, vaccination, and
GDP were included, and the bootstrap confidence interval included zero ([-0.016, 0.061]), indicating age effects
are mediated through other variables.
Panel F: Population Density vs. Deaths. No clear monotonic trend was found (r = -0.063, p = 0.713),
suggesting population density alone is not a strong predictor of mortality. High-density countries showed
heterogeneous outcomes: Singapore and South Korea achieved low mortality through effective public health
responses, while Bangladesh and India experienced moderate mortality, indicating that governance and
healthcare capacity are more important determinants than density alone.
Figure 2: Scatter plots of key relationships among COVID-19 variables
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Hierarchical Regression
Table 3 presents the hierarchical regression results. The base model (Model 1) including only population size
and density explained negligible variance (R² = 0.034). Adding GDP and density (Model 2) increased to
0.564. Inclusion of median age (Model 3) further improved fit to = 0.600. The addition of testing intensity
and positivity rate (Model 4) produced a substantial increase to = 0.897. The full model including vaccination
coverage (Model 5) explained 91.5% of variance (adjusted R² = 0.894).
Table 3: Hierarchical Linear Regression Results
Model
Predictors
Adj. R²
ΔR²
AIC
Model 1
log(Population) + log(Density)
0.034
0.005
88.9
Model 2
+ log(GDP)
0.564
0.523
0.530
64.3
Model 3
+ Median age
0.600
0.549
0.036
63.1
Model 4
+ log(Tests) + Positivity
0.897
0.876
0.297
18.3
Model 5
+ Vaccination
0.915
0.894
0.018
13.4
Note: N = 36. Dependent variable is log₁₀ (Deaths per 1M + 1).
Parsimonious Model
Given the multicollinearity observed in the full model and the limited sample size (n = 36), a parsimonious
model was specified with four predictors: positivity rate (arcsine transformed), vaccination coverage (scaled 0-
1), log (GDP per capita), and median age. This model achieved a subject-to-predictor ratio of 9:1 and produced
VIF values below 10 for all predictors (range: 2.92-8.99).
Table 4 presents the parsimonious model results. The model explained 89.2% of variance in log-transformed
death rates (adjusted R² = 0.878, F(4,31) = 64.19, p < 0.001). Positivity rate was the strongest predictor in terms
of coefficient magnitude = 10.51, 95% CI [8.32, 12.69], p < 0.001), followed by log (GDP per capita) =
1.39, 95% CI [0.93, 1.86], p < 0.001). Vaccination coverage showed a positive association = 0.74, 95% CI
[0.17, 1.30], p = 0.012). Median age was not statistically significant (β = 0.02, 95% CI [-0.01, 0.05], p = 0.132).
Table 4: Parsimonious Linear Regression Results
Predictor
β
SE
t
p
95% CI
Constant
-6.78
0.85
-7.98
<0.001
[-8.52, -5.05]
Positivity rate (arcsin)
10.51
1.07
9.81
<0.001
[8.32, 12.69]
Vaccination coverage (scaled)
0.74
0.28
2.67
0.012
[0.17, 1.30]
log(GDP per capita)
1.39
0.23
6.10
<0.001
[0.93, 1.86]
Median age (years)
0.02
0.01
1.55
0.132
[-0.01, 0.05]
Note: Dependent variable: log₁₀ (Deaths per 1M + 1). Model fit: R² = 0.892, adjusted = 0.878, F(4,31) =
64.19, p < 0.001. Bootstrap 95% confidence intervals based on 1,000 resamples.
SHAP Analysis
To interpret the parsimonious model and assess feature importance beyond traditional regression coefficients,
SHAP (SHapley Additive exPlanations) analysis was employed. GDP per capita (log_GDP_cap) emerged as the
most important feature (mean |SHAP| = 0.3987, 41.7% of total importance), followed by median age (0.2680,
28.1%), vaccination coverage (0.1528, 16.0%), and positivity rate (0.1358, 14.2%). This ordering differs from
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the regression coefficients, where positivity rate had the largest coefficient, highlighting an important distinction:
while positivity rate has a large marginal effect when considered in isolation, its unique contribution after
accounting for other variables is smaller than that of GDP and age.
Figure 3: Mean absolute SHAP values for each predictor
In table 5, Mean |SHAP| values represent the average absolute contribution of each feature to the model's
predictions. Proportion indicates the percentage of total SHAP importance.
Table 5: SHAP Feature Importance Statistics
Feature
Mean |SHAP|
Proportion
Range (Min)
Range (Max)
log_GDP_cap
0.3987
41.7%
-0.7387
0.4580
Median_age
0.2680
28.1%
-0.6734
0.2785
Vaccination_pct
0.1528
16.0%
-0.6597
0.2249
Positivity_pct
0.1358
14.2%
-0.3655
0.2055
The SHAP summary plot reveals the directional effects and variability of each feature. For log_GDP_cap, higher
values consistently increased predicted mortality (red points predominantly on the right side), with SHAP values
ranging from -0.74 to 0.46. This finding, while counterintuitive, reflects more complete death reporting in high-
income countries rather than higher true mortality risk. Median age showed a similar pattern but with greater
heterogeneity: some older countries (particularly in East Asia) showed negative SHAP values, indicating
successful mitigation of age-related risk through effective public health responses.
Vaccination coverage exhibited the widest SHAP value range (-0.66 to 0.22), with both high and low values
producing positive contributions. This pattern supports the reverse causality interpretation: countries that
experienced high mortality implemented aggressive vaccination campaigns, creating a positive ecological
association that does not reflect causal protection at the individual level. The negative SHAP values for some
high-vaccination countries (e.g., Singapore, South Korea) represent successful vaccine rollout in low-
transmission settings.
Positivity rate showed the narrowest range (-0.37 to 0.21) and smallest mean contribution, suggesting that
transmission intensity, while theoretically important, adds limited predictive value beyond economic and
demographic factors in cross-country analyses. The SHAP analysis reinforces that economic development and
population age structure are the dominant drivers of cross-country variation in reported COVID-19 mortality,
with transmission metrics providing secondary explanatory power.
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Figure 4: SHAP summary plot for the parsimonious model
In Figure 4, each point represents a country, with colors indicating the feature value (red = high, blue = low).
The x-axis shows the SHAP value (impact on the model's prediction). Points to the right of zero increase the
predicted death rate; points to the left decrease it.
Subgroup Analyses
The association between positivity rate and log-transformed deaths varied substantially by GDP stratum (Table
6). The correlation was strongest in high-GDP countries (r = 0.898, p < 0.001), followed by low-GDP countries
(r = 0.597, p = 0.019) and medium-GDP countries (r = 0.525, p = 0.119). Fisher's z-test indicated that the
correlation in high-GDP countries was significantly larger than in medium-GDP countries (z = 2.14, p = 0.032)
but not significantly different from low-GDP countries (z = 1.72, p = 0.085).
Table 6: Subgroup Analysis: Positivity-Deaths Correlation by GDP Stratum
GDP Category
n
Correlation (r)
p-value
Low
12
0.597
0.019
Medium
12
0.525
0.119
High
12
0.898
<0.001
Note: Correlations are between positivity rate (%) and log₁₀ (Deaths per 1M + 1).
MAJOR FINDINGS
The principal findings from this analysis can be summarized as follows. Positivity rate showed the largest
regression coefficient (β = 10.51, p < 0.001), indicating a large marginal effect when considered in isolation, yet
ranked fourth in SHAP importance (14.2%), suggesting its unique contribution diminishes after accounting for
other factors. Conversely, GDP per capita ranked first in SHAP importance (41.7%), driving reporting
completeness, with a moderate regression coefficient (β = 1.39, p < 0.001). The parsimonious model explained
89.2% of variance in reported death rates (R² = 0.892, adjusted = 0.878, F(4,31) = 64.19, p < 0.001). The
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positivity-deaths correlation was strongest in high-GDP countries (r = 0.898, p < 0.001), reflecting more
complete death reporting. Vaccination coverage showed a positive coefficient = 0.74, p = 0.012), which
reflects reverse causality rather than a protective effect, as countries with higher death tolls implemented more
aggressive vaccination campaigns. Median age was not statistically significant in the parsimonious model =
0.02, p = 0.132), with the bootstrap confidence interval including zero ([-0.016, 0.061]), indicating that age
effects are mediated through other variables such as GDP and healthcare capacity. Cross-validated performance
was positive for the linear model but negative for eXtreme Gradient Boosting (XGBoost) (R² = -0.324),
suggesting that linear models with careful variable selection are more appropriate for this sample size.
DISCUSSION
This stratified analysis of 36 countries suggests three principal findings. First, positivity rate appeared as the
strongest predictor of cumulative COVID-19 mortality, with a large effect size = 10.51) that remained
consistent across model specifications. Second, the parsimonious model including only positivity rate,
vaccination coverage, GDP per capita, and median age accounted for 89% of cross-country variation in death
rates. Third, the association between positivity rate and mortality was most pronounced in high-GDP countries,
a pattern that likely reflects substantial differences in data reliability and death reporting completeness across
income strata.
Data Reliability and Under-Reporting in Low-GDP Countries
A central challenge in cross-country COVID-19 comparisons concerns the marked heterogeneity in testing
capacity and death registration across income levels. In low-GDP countries, testing intensity was considerably
lower (mean 1,600 tests per 100k) compared to high-GDP countries (mean 63,000 tests per 100k). This disparity
likely resulted in substantial under-ascertainment of both cases and deaths in low-resource settings.
Consequently, reported deaths in low-GDP countries (mean 167 per 1M) may substantially underestimate true
mortality, a concern well documented in the literature (Msemburi et al., 2023). The weaker positivity-deaths
correlation observed in low-GDP countries (r = 0.597) compared to high-GDP countries (r = 0.898) may
therefore reflect differential reporting completeness rather than genuinely different biological or epidemiological
relationships. This suggests that the true association between community transmission and mortality could be
considerably stronger than estimates herein indicate, particularly in settings where testing and vital registration
systems are least developed.
Positivity Rate as a Key Metric
The observation that positivity rate outperformed testing volume as a predictor of mortality may carry important
public health implications, particularly given concerns about data reliability. Although testing intensity showed
a strong positive correlation with deaths (r = 0.688), this likely reflects reverse causality: countries experiencing
high mortality expanded testing capacity reactively. More importantly, testing intensity is highly sensitive to
reporting completeness, whereas positivity ratethe proportion of tests returning positivemay be less
influenced by absolute testing volume once a minimum threshold is reached. The World Health Organization
has recommended that positivity rates remain below 5% for 14 days before reopening, a benchmark that high-
GDP countries in our sample achieved (mean = 3.0%) but low-GDP countries did not (mean = 10.2%). Notably,
even this benchmark may be difficult to interpret in settings with extremely low testing capacity, where high
positivity rates could reflect both intense transmission and inadequate surveillance.
The magnitude of the positivity effect appears substantial. Although the arcsine transformation complicates
direct interpretation, the coefficient = 10.51) suggests that a 10-percentage point increase in positivity rate
may be associated with approximately a 1.8-fold increase in predicted deaths per million, holding other variables
constant. However, this estimate likely depends on the assumption that death reporting is equally complete across
countriesan assumption that probably does not hold.
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The Role of GDP and Testing
The positive association between GDP per capita and deaths (β = 1.39, p < 0.001) seems counterintuitive given
that wealthier countries had better healthcare infrastructure. This finding likely reflects three interrelated
phenomena, two of which concern data reliability. First, wealthier countries almost certainly had more complete
death reporting, reducing undercount bias. Second, high-GDP countries had older populations (median age 42.4
vs. 22.5 years), increasing biological susceptibility. Third, high-GDP countries experienced earlier and larger
epidemic waves before vaccines became available. The strong association between GDP and reported deaths
may therefore be partially nonfactual, driven by systematic differences in the completeness of vital registration
systems rather than true differences in mortality risk.
The elevated variance inflation factors observed for GDP, testing, and age suggest that these variables share
substantial common variance, making it difficult to disentangle true biological effects from reporting artifacts.
The parsimonious model reduced but did not eliminate this issue (VIF range: 2.92-8.99).
Vaccination and Reverse Causality
The positive association between vaccination coverage and deaths = 0.74, p = 0.012) requires careful
interpretation and may also be influenced by reporting heterogeneity. This finding likely does not indicate that
vaccination increased mortalitya conclusion contradicted by clinical trial evidence (Polack et al., 2020; Baden
et al., 2021). Instead, it may reflect reverse causality: countries with higher death tolls implemented more
aggressive vaccination campaigns. In our sample, high-GDP countries had both higher vaccination coverage
(81.9%) and higher reported deaths (1,186 per million) compared to low-GDP countries (35.4% vaccination,
167 reported deaths). However, it remains possible that under-reporting of deaths in low-GDP countries also
contributes to this pattern, as lower reported deaths may have reduced perceived urgency for vaccination
campaigns in some settings.
Subgroup Differences by GDP and Reporting Implications
The observation that the positivity-deaths correlation was strongest in high-GDP countries (r = 0.898) compared
to low-GDP countries (r = 0.597) may primarily reflect differential death reporting quality rather than true
biological differences. In low-income settings, both testing and death registration are incomplete (Msemburi et
al., 2023), potentially attenuating observed correlations. This suggests that the true association between
community transmission and mortality could be even stronger than our estimates indicate, particularly in low-
resource settings where under-reporting is most severe. Conversely, the very strong correlation observed in high-
GDP countries (r = 0.898) may approach the true underlying relationship, as these settings have more complete
testing and vital registration systems.
Comparison with Previous Literature
Our findings generally align with and extend previous research, though direct comparisons are complicated by
heterogeneous data quality across studies. Thorp et al. (2023) reported that GDP (r = 0.50) and vaccination (r =
0.39) correlated with deaths across 108 countries, though their analysis did not include positivity rate as a
separate predictor. Klement and Walach (2022) found that testing and prior influenza vaccination were the
strongest predictors in 43 European countries, explaining approximately 66% of variance. Our parsimonious
model achieved higher explanatory power (adjusted R² = 0.878), possibly due to the inclusion of positivity rate
as a direct measure of transmission intensity and the stratified design that reduced between-country
heterogeneity. However, the higher explanatory power may also reflect the narrower range of data quality in our
stratified sample, which included sufficient representation of high-GDP countries with more reliable reporting.
The C-MOR project (Rahmanian Haghighi et al., 2024) emphasized the importance of vaccination and
government stringency, but their analysis focused on excess mortality rather than reported deaths. Excess
mortality estimates attempt to circumvent under-reporting by modeling expected deaths from historical trends,
representing a potentially more robust approach for cross-country comparisons. Our reliance on reported deaths
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limits comparability with such studies but aligns with routinely available surveillance data, which remains the
primary information source for real-time pandemic response.
Limitations
Some of the notable limitations include data reliability concerns. First, the ecological design precludes
individual-level causal inference. The associations observed at the country level may not hold at the individual
level, and unmeasured confounding cannot be ruled out. Second, death reporting varied substantially across
countries. In low-income settings, under-counting is well documented (Msemburi et al., 2023). The stronger
positivity-deaths correlation in high-GDP countries strongly suggests that reporting bias may substantially
attenuate observed effects in low-resource settings. Thus our estimates likely underestimate the true association
between transmission intensity and mortality. Third, testing capacity itself varied dramatically across income
strata, with low-GDP countries achieving mean testing rates of only 1,600 tests per 100,000 compared to 63,000
tests per 100,000 in high-GDP countries (Knipper et al., 2025). This disparity likely resulted in systematic under-
ascertainment of cases, which may have biased positivity rate estimates, particularly in settings where testing
was primarily symptomatic. Fourth, the positive association between vaccination coverage and mortality likely
reflects reverse causality rather than a causal effect. Countries with higher death tolls vaccinated more
aggressively. This ecological fallacy represents a known limitation of cross-country comparisons and should not
be misinterpreted as evidence against vaccine effectiveness. Fifth, the sample size (n = 36) limited statistical
power for detecting small effects and precluded testing of three-way interactions. The parsimonious model
achieved an acceptable subject-to-predictor ratio (9:1), though replication in larger samples would strengthen
confidence in these findings. Sixth, the cross-sectional design captures associations at a single time point
(December 2022) but does not account for temporal dynamics. The timing of epidemic waves, variant
emergence, and vaccination rollout varied substantially across countries, and our static analysis cannot
disentangle these temporal effects. Seventh, the positivity rate measure uses peak 7-day average rather than time-
averaged values. While this captures maximum transmission intensity, it may not fully reflect cumulative
exposure over the pandemic period, particularly in countries with multiple waves.
CONCLUSIONS
In this stratified analysis of 36 countries representing diverse economic and demographic profiles, positivity rate
emerged as the strongest predictor of COVID-19 mortality among the variables examined. However, this finding
must be interpreted in light of substantial heterogeneity in data quality across income strata. A parsimonious
model including positivity rate, vaccination coverage, GDP per capita, and median age accounted for 89% of
cross-country variation in reported death rates, though this high explanatory power may partly reflect systematic
reporting differences between high- and low-GDP countries.
The association between positivity and mortality appeared most pronounced in high-GDP countries (r = 0.898),
where testing and death registration are most complete. In contrast, the weaker correlation observed in low-GDP
countries (r = 0.597) likely reflects substantial under-reporting of deaths rather than a genuinely different
biological relationship. This suggests that the true association between community transmission and mortality
could be considerably stronger than our estimates indicate, particularly in low-resource settings where
surveillance systems are least developed.
These findings carry practical public health implications, though they must be applied with caution across
different settings. Maintaining low positivity rates through accessible, widespread testing could serve as a
cornerstone of pandemic surveillance and response, particularly where vital registration systems are reliable.
The World Health Organization's benchmark of <5% positivity for 14 days before reopening provides an
evidence-based target, though achieving this benchmark may be challenging in low-resource settings with
limited testing capacity. Routine monitoring of positivity rates might offer early warning of resurgence before
hospitalizations and deaths increase, enabling timely implementation of targeted interventions.
Future research should examine whether the positivity-mortality association holds at subnational levels, where
data quality may be more homogeneous, and whether similar patterns emerge for other respiratory pathogens.
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Prospective studies with standardized reporting protocols and investment in vital registration infrastructure
would strengthen causal inference. Additionally, research on the barriers to achieving low positivity rates in low-
resource settings remains urgently needed to ensure equitable pandemic preparedness. Methodological work to
develop correction factors for under-reporting based on testing intensity and other indicators would also
substantially improve cross-country comparisons.
ACKNOWLEDGMENTS
The author thanks the Our World in Data team, World Bank, and United Nations Population Division for making
their data publicly available.
Conflict of Interest Disclosure
The author declares no competing interests.
Funding
This research received no specific grant from funding agencies in the public, commercial, or not-for-profit
sectors.
Data Availability
The dataset and Python code supporting this analysis are available from the author on request.
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APPENDIX
Supplementary Materials
Supplementary Table 1. Country classification by GDP per capita and population density strata
Country
GDP category
Density category
Niger
Low
Low
Chad
Low
Low
Mali
Low
Low
Burkina Faso
Low
Low
Nigeria
Low
Medium
Cameroon
Low
Medium
India
Low
Medium
Pakistan
Low
Medium
Bangladesh
Low
High
Philippines
Low
High
Rwanda
Low
High
Haiti
Low
High
Brazil
Medium
Low
Mexico
Medium
Low
Russia
Medium
Low
Argentina
Medium
Low
China
Medium
Medium
Turkey
Medium
Medium
Thailand
Medium
Medium
Colombia
Medium
Medium
Vietnam
Medium
High
Indonesia
Medium
High
Egypt
Medium
High
Morocco
Medium
High
Australia
High
Low
Canada
High
Low
Norway
High
Low
Finland
High
Low
France
High
Medium
Spain
High
Medium
Poland
High
Medium
United Kingdom
High
Medium
Netherlands
High
High
South Korea
High
High
Japan
High
High
Singapore
High
High
Note: GDP categories: Low (<$4,000), Medium ($4,000-$25,000), High (>$25,000). Density categories:
Low (<50 persons/km²), Medium (50-200 persons/km²), High (>200 persons/km²). Complete data are
available from the corresponding author upon request.