Medicinal Chemistry, Pharmacokinetics and Drug-Likeness Properties of Some Azetidinone Derivatives via Swiss-ADME Tool

Abstract: Azetidinone derivatives, known for their potent biological activities, have garnered significant attention in medicinal chemistry. Swiss ADME, a web-based computational tool, is used in the present study to assess the pharmacokinetics and drug-likeness profiles of certain azetidinone derivatives. A comprehensive in-silico analysis was conducted to predict key parameters such as absorption, distribution, metabolism, and excretion (ADME), alongside physicochemical properties, lipophilicity, water solubility, and bioavailability scores. The drug-likeness was assessed using Lipinski's Rule of Five and other medicinal chemistry filters. Results revealed that most of the azetidinone derivatives exhibit favourable pharmacokinetic profiles with high gastrointestinal absorption, moderate to high lipophilicity, and good oral bioavailability. Several compounds also complied with multiple drug-likeness filters, indicating promising lead-like characteristics. These results highlight the potential of Swiss ADME as a predictive tool in early-stage drug development and offer insightful information for the logical design and optimisation of azetidinone-based therapies.