Stabilisation of Curcumin for Delivery Inside Live Cell
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Curcumin, widely used as spice in Asia is found in rhizome of turmeric plant (Curcuma longa and Curcuma xanthorrhiza). It shows antibacterial, anti-inflammatory, hypoglycemic, antioxidant, antimicrobial activities and capable of treating fatal disease like cancer, Parkinson’s disease. It is highly unstable in aqueous solution specially in high pH condition makes it deceptively useful. In this this review we have shown several techniques and schemes that made curcumin a potent useful drug. Forming complex with proteins, lipids, lipoproteins, cyclodextrin and bio-mimicking molecules is effective to increase bioavailability of this hydrophobic molecule. Nature of interactions and binding mechanism with those molecules are discussed here. Most important aspect of this review is to deliver curcumin inside live cells and finding the effects on cell death (apoptosis) and proliferations. Different drug delivery systems have been developed which show excellent rate of internalisation. Curcumin has been delivered intravenously in live mouse model.
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