Performance of Procalcitonin and Reactive Protein-C in the Diagnosis of Early Neonatal Infection At the C.H.U of Brazzaville

Summary

The aim of this study was to evaluate the performance of procalcitonin and C-reactive protein in the diagnosis of early neonatal infection at Brazzaville University Hospital. This is a cross-sectional analytical study of 43 patients followed up in the Neonatology Department of the Brazzaville University Hospital Centre between July and November 2021. Procalcitonin, C-reactive protein and blood cultures were positive in 90.7%, 37.2% and 60% of cases respectively. The p-value was significant for procalcitonin (p = 0.001). The performance criteria for the biomarkers studied evolved in the opposite direction. However, the sensitivities of procalcitonin and C-reactive protein were 100% and 42.3% respectively, and the specificities of these biomarkers were 70.6% and 23.5% respectively. Procalcitonin cannot be used as the sole marker of neonatal infection ; it must always be combined with C-reactive protein.

neonatal infection, procalcitonin, C-reactive protein, Congo

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