Development of A Machine Learning Model for Multiple Disease Prediction
Authors
D. U. Ashishie
Department of Computer Science, University of Calabar, Calabar, Nigeria (NG)
D. O. Egete
Department of Computer Science, University of Calabar, Calabar, Nigeria (NG)
B. I. Ele
Department of Computer Science, University of Calabar, Calabar, Nigeria (NG)
Article Information
DOI: 10.51583/IJLTEMAS.2025.1408000058
Subject Category: Computer Science
Volume/Issue: 14/8 | Page No: 480-492
Publication Timeline
Submitted: 2025-09-06
Published: 2025-09-06
Abstract
Abstract: The growing incident of various diseases globally underscores the urgent need for innovative healthcare solutions. This study focused on developing an improved machine learning-based system for predicting multiple diseases. By evaluating the probability of illnesses using patient data, the primary goal is to aid medical professionals in the early diagnosis and personalized management of conditions such as cancer, diabetes, and cardiovascular diseases. The approach employs supervised learning algorithms to analyze medical datasets and provide accurate disease predictions. Several methods, including decision trees, support vector machines, and neural networks, were explored to identify the optimal model based on accuracy and computational efficiency. The system was trained and validated using diverse medical datasets that were preprocessed to address noise and missing values. The architecture of the system was elaborated, detailing steps such as data preparation, model training, and interpretation of results. The performance of the system was rigorously evaluated using key metrics like accuracy, precision, recall, and F1-score. Findings from this study indicate that this approach can serve as a valuable tool in clinical decision-making, delivering highly accurate predictions for various diseases. This work highlights the potential of machine learning to enhance diagnostic processes, leading to faster and more effective treatments. Future efforts will focus on incorporating real-time data for dynamic updates and extending the system's functionality to predict a broader range of diseases.
Keywords
Machine learning, multi-disease prediction, supervised learning, healthcare, decision trees, support vector machines, neural networks, medical datasets, diagnostic tool, predictive model
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References
1. Ahmad, L. G., Kalhori, S. R., Malaekeh, N. B. & Tavakkoli-Moghaddam, R. (2018). Machine learning techniques for predicting diabetes. Journal of Medical Systems, 42(12), 235. https://doi.org/10.1007/s10916-018-1072-6 [Google Scholar] [Crossref]
2. Breiman, L. (2001). Random forests. Machine Learning, 45(1), 5-32. https://doi.org/10.1023/A:1010933404324 [Google Scholar] [Crossref]
3. Caruana, R., Lou, Y., Gehrke, J., Koch, P., Sturm, M., & Elhadad, N. (2015). Intelligible models for healthcare: Predicting pneumonia risk and hospital 30-day readmission. In Proceedings of the 21th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining (1721-1730). https://doi.org/10.1145/2783258.2788613 [Google Scholar] [Crossref]
4. Challen, R., Denny, J., Pitt, M., Gompels, L., Edwards, R., & Tsaneva-Atanasova, K. (2019). Artificial intelligence, bias, and clinical safety. BMJ Quality & Safety, 28(3), 231-237. https://doi.org/10.1136/bmjqs-2018-008370 [Google Scholar] [Crossref]
5. Chen, T., & Guestrin, C. (2016). XGBoost: A scalable tree boosting system. In Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining (pp. 785-794). [Google Scholar] [Crossref]
6. https://doi.org/10.1145/2939672.2939785 [Google Scholar] [Crossref]
7. Chen, Y., Li, X., & Xu, S. (2017). Predicting multiple diseases based on behavioral data using machine learning. IEEE Transactions on Neural Networks and Learning Systems, 28(2), 1231-1241. [Google Scholar] [Crossref]
8. https://doi.org/10.1109/TNNLS.2016.2597167 [Google Scholar] [Crossref]
9. Chicco, D., Jurman, G., & Moschitti, A. (2020). Machine learning can predict survival of patients with heart failure from serum creatinine and ejection fraction alone. BMC Medical Informatics and Decision Making, 20, 16. https://doi.org/10.1186/s12911-020-1023-4 [Google Scholar] [Crossref]
10. Collins, F. S., & Varmus, H. (2015). A new initiative on precision medicine. The New England Journal of Medicine, 372(9), 793-795. https://doi.org/10.1056/NEJMp1500523 [Google Scholar] [Crossref]
11. Doshi-Velez, F., & Kim, B. (2017). Towards a rigorous science of interpretable machine learning. arXiv preprint arXiv:1702.08608. https://doi.org/10.48550/arXiv.1702.08608 [Google Scholar] [Crossref]
12. Esteva, A., Kuprel, B., Novoa, R. A., Ko, J., Swetter, S. M., Blau, H. M., & Thrun, S. (2017). Dermatologist-level classification of skin cancer with deep neural networks. Nature, 542(7639), 115-118. https://doi.org/10.1038/nature21056 [Google Scholar] [Crossref]
13. Esteva, A., Robicquet, A., Ramsundar, B., Kuleshov, V., DePristo, M., Chou, K., Cui, C., Corrado, G. S., Thrun, S., & Dean, J. (2019). A guide to deep learning in healthcare. Nature Medicine, 25(1), 24-29. https://doi.org/10.1038/s41591-018-0316-z [Google Scholar] [Crossref]
14. Ferrucci, D., Brown, E., Chu-Carroll, J., Fan, J., Gondek, D., Kalyanpur, A. A., Lally, A., Murdock, J. W., Nyberg, E., Prager, J., Schlaefer, N., & Welty, C. (2010). Building Watson: An overview of the DeepQA project. AI Magazine, 31(3), 59-79. https://doi.org/10.1609/aimag.v31i3.2303 [Google Scholar] [Crossref]
15. Foster, K. R., Koprowski, R., & Skufca, J. D. (2020). Machine learning, medical diagnosis, and biomedical engineering: The view of a clinical engineer. IEEE Pulse, 11(3), 45-49. https://doi.org/10.1109/MPULS.2020.2986334 [Google Scholar] [Crossref]
16. Gorunescu, F. (2011). Data mining: Concepts, models, and techniques. Springer. https://doi.org/10.1007/978-3-642-19721-5 [Google Scholar] [Crossref]
17. Jiang, F., Jiang, Y., Zhi, H., Dong, Y., Li, H., Ma, S., Wang, Y., Dong, Q., Shen, H., Wang, Y. (2017). Artificial intelligence in healthcare: Past, present, and future. Stroke and Vascular Neurology, 2(4), 230-243. https://doi.org/10.1136/svn-2017-000101 [Google Scholar] [Crossref]
18. John, R., Aro, A. Q., Mathew, R., & Manju, G. (2019). Multidisease prediction using machine learning: A new horizon in healthcare. Journal of Medical Systems, 43(2), 29. https://doi.org/10.1007/s10916-019-1168-8 [Google Scholar] [Crossref]
19. Kourou, K., Exarchos, T. P., Exarchos, K. P., Karamouzis, M. V., & Fotiadis, D. I. (2015). Machine learning applications in cancer prognosis and prediction. Computational and Structural Biotechnology Journal, 13, 8-17. https://doi.org/10.1016/j.csbj.2014.11.005 [Google Scholar] [Crossref]
20. LeCun, Y., Bengio, Y., & Hinton, G. (2015). Deep learning. Nature, 521(7553), 436-444. https://doi.org/10.1038/nature14539 [Google Scholar] [Crossref]
21. Litjens, G., Kooi, T., Bejnordi, B. E., Setio, A. A. A., Ciompi, F., Ghafoorian, M., Van Der Laak, J. A. W. M., Van Ginneken, B., & Sánchez, C. I. (2017). A survey on deep learning in medical image analysis. Medical Image Analysis, 42, 60-88. https://doi.org/10.1016/j.media.2017.07.005 [Google Scholar] [Crossref]
22. Miotto, R., Li, L., Kidd, B. A., & Dudley, J. T. (2016). Deep patient: An unsupervised representation to predict the future of patients from the electronic health records. Scientific Reports, 6, 26094. https://doi.org/10.1038/srep26094 [Google Scholar] [Crossref]
23. Mittelstadt, B. D. (2019). Principles alone cannot guarantee ethical AI. Nature Machine Intelligence, 1(11), 501-507. https://doi.org/10.1038/s42256-019- 0114-4 [Google Scholar] [Crossref]
24. Obermeyer, Z., Powers, B., Vogeli, C., & Mullainathan, S. (2019). Dissecting racial bias in an algorithm used to manage the health of populations. Science, 366(6464), 447-453. https://doi.org/10.1126/science.aax2342 [Google Scholar] [Crossref]
25. Rajkomar, A., Oren, E., Chen, K., Dai, A. M., Hajaj, N., Liu, P. J., Liu, X., Marcus, J., Sun, M., Sundberg, P., Yee, H., Zhang, K., Zhang, Y., Flores, G., Duggan, G. E., Dean, J., Maisel, M., Wing, P., & Ewig, M. (2018). Scalable and accurate deep learning for electronic health records. NPJ Digital Medicine, 1(1), 18. https://doi.org/10.1038/s41746-018-0029-1 [Google Scholar] [Crossref]
26. Razzak, M. I., Naz, S., & Zaib, A. (2018). Deep learning for medical image processing: Overview, challenges, and the future. Current Medical Imaging Reviews, 14(5), 574-585. https://doi.org/10.2174/1573405614666180907121327 [Google Scholar] [Crossref]
27. Reddy, S., Allan, S., Coghlan, S., & Cooper, P. (2020). A governance model for the application of AI in health care. Journal of the American Medical Informatics Association, 27(7), 1110-1114. https://doi.org/10.1093/jamia/ocaa018 [Google Scholar] [Crossref]
28. Rudin, C. (2019). Stop explaining black box machine learning models for high stakes decisions and use interpretable models instead. Nature Machine Intelligence, 1(5), 206-215. https://doi.org/10.1038/s42256-019-0048-x [Google Scholar] [Crossref]
29. Shen, J., Zhang, C. J. P., Jiang, B., Chen, J., Song, J., Liu, Z., He, Z., & Wong, S. Y. (2020). Applications of artificial intelligence in medical education and practice: The future is now. Frontiers in Medicine, 7, 149. https://doi.org/10.3389/fmed.2020.00149 [Google Scholar] [Crossref]
30. Siegel, R. L., Miller, K. D., & Jemal, A. (2020). Cancer statistics, 2020. CA: A Cancer Journal for Clinicians, 70(1), 7-30. https://doi.org/10.3322/caac.21590 [Google Scholar] [Crossref]
31. Tomašev, N., Glorot, X., Rae, J. W., Zielinski, M., Askham, H., Saraiva, A., Mottram, A., Meyer, C., Ravuri, S., Protsyuk, I., Connell, A., Hughes, C. O., Karthikesalingam, A., Jelley, A., Peterson, K., Rees, G., Laing, C., Shetty, S., Tarte, S., ... De Fauw, J. (2019). A clinically applicable approach to predicting acute kidney injury in hospitalized patients. Nature, 572(7767), 116-119. https://doi.org/10.1038/s41586-019-1390-1 [Google Scholar] [Crossref]
32. Topol, E. J. (2019). High-performance medicine: The convergence of human and artificial intelligence. Nature Medicine, 25(1), 44-56. https://doi.org/10.1038/s41591-018-0300-7 [Google Scholar] [Crossref]
33. Wang, F., Casalino, L. P., & Khullar, D. (2020). Deep learning for multi-disease prediction. Journal of Biomedical Informatics, 112, 103604. https://doi.org/10.1016/j.jbi.2020.103604 [Google Scholar] [Crossref]
34. WHO. (2021). Non-communicable diseases. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases. [Google Scholar] [Crossref]
35. Zhang, Z., Missing, C., Nevadunsky, N., Lutomski, C., Taylor, A., Henry, A., & Anagnostopoulos, C. (2021). Missing data in machine learning: A Comprehensive Review. IEEE Access, 9, 95690-95709. https://doi.org/10.1109/ACCESS.2021.309398 [Google Scholar] [Crossref]
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