Environmental-Friendly Hydrogels from Hydroxyethyl Cellulose (HEC)/ Sodium Alginate (SA)/ Hyaluronic Acid (HA) for Wound Healing Applications

Abstract: The aim of the study is to obtain a new hydrogel using HEC/SA/HA via a green chemistry approach for wound healing applications. The properties of the hydrogel have been tested which include: swelling ratio, in vitro degradation, and wound healing test. It was also characterized via UV-Vis, FTIR, TEM, and TGA.  The characteristic peak of UV-Vis spectra revealed the formation of AgNPs in the compound at 411 nm. The results from these studies showed that the hydrogel has an excellent performance in swelling ratio and vitro degradation. Furthermore, the wound healing activity of the hydrogel was tested by measuring the closure of the wound and the hydrogel used in the treated group revealed a significant healing activity compared to the control group. These results suggested that the cross-linked hydrogel based on (HEC/HA/SA) with AgNPs will be a promising dressing for wounds.

Hyaluronic acid (HA), Sodium alginate (SA), Hydroxyethyl cellulose (HEC), Silver nano-particles (AgNPs), Tissue engineering (TE)

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