Biogenic Nanoparticle Synthesis Using Ganoderma Macrofungi and Its Biomedical and Environmental Applications

Ganoderma is a notable Indian conventional mushroom utilized in different ethnomedicinal practices. New advancements connected with this mushroom and their exercises are consistently reported. A few researchers working with spores of this therapeutic mushroom however data of this species are still limited. This review describes about the main advances for the extraction of biocomponents and their pharmacological and cell protective effects on health system because of their importance in drug discovery. Recognizing the bioavailability of the naturally dynamic parts of G. lucidum after oral administration, and very little has been published in this area. Although single compounds can mediate a biological effect, nutraceuticals often act through the synergistic activity of multiple metabolites. It is significant to gain a better understanding of the bioavailability of the active components in this mushroom under various conditions to ensure robust study designs and to maximise consumer advantage. Nanoparticles derived from macro fungi, including various mushroom species like Ganoderma spp. are well known to possess immune-modulatory, high nutritional, antimicrobial, antioxidant, and anticancerous effect. Fungi have intracellular metal uptake capacity and supreme wall binding ability. In this review also discussed the nanoparticles synthesis from micro fungi of Ganoderma species and mechanism of nanoparticles derived from the micro fungus.

mushroom, biomedical, compounds, peptidoglycan, immunomodulation

1. S. Zafar, S. Beg, S.K. Panda, M. Rahman, K.S. Alharbi, G.K. Jain, F.J. Ahmad, Novel therapeutic interventions in cancer treatment using protein and peptide-based targeted smart systems, Semin. Cancer Biol. 69 (2021) 249–267. https://doi.org/10.1016/j.semcancer.2019.08.023. [Google Scholar] [Crossref]

2. M.M. Al-Ansari, P. Dhasarathan, A.J.A. Ranjitsingh, L.A. Al-Humaid, Ganoderma lucidum inspired silver nanoparticles and its biomedical applications with special reference to drug resistant Escherichia coli isolates from CAUTI, Saudi J. Biol. Sci. 27 (2020) 2993–3002. https://doi.org/10.1016/j.sjbs.2020.09.008. [Google Scholar] [Crossref]

3. Y. Jing, J. Li, Y. Zhang, R. Zhang, Y. Zheng, B. Hu, L. Wu, D. Zhang, Structural characterization and biological activities of a novel polysaccharide from Glehnia littoralis and its application in preparation of nano-silver, Int. J. Biol. Macromol. 183 (2021) 1317–1326. https://doi.org/10.1016/j.ijbiomac.2021.04.178. [Google Scholar] [Crossref]

4. Y. Zhu, T.L. Tan, Penalized discriminant analysis for the detection of wild-grown and cultivated Ganoderma lucidum using Fourier transform infrared spectroscopy, Spectrochim. Acta - Part A Mol. Biomol. Spectrosc. 159 (2016) 68–77. https://doi.org/10.1016/j.saa.2016.01.018. [Google Scholar] [Crossref]

5. Y. Kan, T. Chen, Y. Wu, J. Wu, J. Wu, Antioxidant activity of polysaccharide extracted from Ganoderma lucidum using response surface methodology, Int. J. Biol. Macromol. 72 (2015) 151–157. https://doi.org/10.1016/j.ijbiomac.2014.07.056. [Google Scholar] [Crossref]

6. S. Zhang, G. Pang, C. Chen, J. Qin, H. Yu, Y. Liu, X. Zhang, Z. Song, J. Zhao, F. Wang, Y. Wang, L.W. Zhang, Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response, Carbohydr. Polym. 205 (2019) 192–202. https://doi.org/10.1016/j.carbpol.2018.10.028. [Google Scholar] [Crossref]

7. S. Jogaiah, M. Kurjogi, M. Abdelrahman, N. Hanumanthappa, L.S.P. Tran, Ganoderma applanatum-mediated green synthesis of silver nanoparticles: Structural characterization, and in vitro and in vivo biomedical and agrochemical properties, Arab. J. Chem. 12 (2019) 1108–1120. https://doi.org/10.1016/j.arabjc.2017.12.002. [Google Scholar] [Crossref]

8. J. Si, Y. Wu, H.F. Ma, Y.J. Cao, Y.F. Sun, B.K. Cui, Selection of a pH- and temperature-stable laccase from Ganoderma australe and its application for bioremediation of textile dyes, J. Environ. Manage. 299 (2021). https://doi.org/10.1016/j.jenvman.2021.113619. [Google Scholar] [Crossref]

9. R. Nag, S. Nolan, V. O’Flaherty, O. Fenton, K.G. Richards, B.K. Markey, P. Whyte, D. Bolton, E. Cummins, Quantitative microbial human exposure model for faecal indicator bacteria and risk assessment of pathogenic Escherichia coli in surface runoff following application of dairy cattle slurry and co-digestate to grassland, J. Environ. Manage. 299 (2021) 113627. https://doi.org/10.1016/j.jenvman.2021.113627. [Google Scholar] [Crossref]

10. E. Rani, S.A. Mohshim, N.H. Yusof, M.Z. Ahmad, R. Goodacre, S.A. Alang Ahmad, L.S. Wong, Sensitive and selective detection of DNA fragments associated with Ganoderma boninense by DNA-nanoparticle conjugate hybridisation, J. Mater. Sci. 55 (2020) 14965–14979. https://doi.org/10.1007/s10853-020-05058-8. [Google Scholar] [Crossref]

11. A. Aygün, S. Özdemir, M. Gülcan, K. Cellat, F. Şen, Synthesis and characterization of Reishi mushroom-mediated green synthesis of silver nanoparticles for the biochemical applications, J. Pharm. Biomed. Anal. 178 (2020). https://doi.org/10.1016/j.jpba.2019.112970. [Google Scholar] [Crossref]

12. D. Zheng, J. Zhao, Y. Tao, J. Liu, L. Wang, J. He, J. Lei, K. Liu, pH and glutathione dual responsive nanoparticles based on Ganoderma lucidum polysaccharide for potential programmable release of three drugs, Chem. Eng. J. 389 (2020) 124418. https://doi.org/10.1016/j.cej.2020.124418. [Google Scholar] [Crossref]

13. X. Wang, X. Chen, Z. Qi, X. Liu, W. Li, S. Wang, A study of Ganoderma lucidum spores by FTIR microspectroscopy, Spectrochim. Acta - Part A Mol. Biomol. Spectrosc. 91 (2012) 285–289. https://doi.org/10.1016/j.saa.2012.02.004. [Google Scholar] [Crossref]

14. S.Y. Abdul-Hadi, M.N. Owaid, M.A. Rabeea, A. Abdul Aziz, M.S. Jameel, Rapid mycosynthesis and characterization of phenols-capped crystal gold nanoparticles from Ganoderma applanatum, Biocatal. Agric. Biotechnol. 27 (2020) 101683. https://doi.org/10.1016/j.bcab.2020.101683. [Google Scholar] [Crossref]

15. S.A. Fowotade, N.A. Yusof, J. Abdullah, Y. Sulaiman, S.F. Abd Rahman, Enhanced electrochemical sensing of secondary metabolites in oil palms for early detection of Ganoderma boninense, Sens. Bio-Sensing Res. 23 (2019) 100274. https://doi.org/10.1016/j.sbsr.2019.100274. [Google Scholar] [Crossref]

16. G. Krishna, V. Srileka, M.A. Singara Charya, E.S. Abu Serea, A.E. Shalan, Biogenic synthesis and cytotoxic effects of silver nanoparticles mediated by white rot fungi, Heliyon. 7 (2021) e06470. https://doi.org/10.1016/j.heliyon.2021.e06470. [Google Scholar] [Crossref]

17. T. Do Dat, N.D. Viet, N.M. Dat, P.L.T. My, D.B. Thinh, L.T.M. Thy, L.M. Huong, P.T. Khang, N.D. Hai, H.M. Nam, M.T. Phong, N.H. Hieu, Characterization and bioactivities of silver nanoparticles green synthesized from Vietnamese Ganoderma lucidum, Surfaces Interfaces. 27 (2021) 101453. https://doi.org/10.1016/j.surfin.2021.101453. [Google Scholar] [Crossref]

18. M. Al Harbi, A.A. Tayel, Synergistic in vitro anticancer actions of decorated selenium nanoparticles with fucoidan/Reishi extract against colorectal adenocarcinoma cells, (2022) 373–384. [Google Scholar] [Crossref]

19. H. Pan, Y. Wang, K. Na, Y. Wang, L. Wang, Z. Li, C. Guo, D. Guo, X. Wang, Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation, Cell Death Dis. 10 (2019). https://doi.org/10.1038/s41419-019-1653-7. [Google Scholar] [Crossref]

20. A. Isha, F.S. Akanbi, N.A. Yusof, R. Osman, W. Mui-Yun, S.N.A. Abdullah, NMR metabolomics approach for detection of Ganoderma boninense-infected oil palm leaves, J. Nanomater. 2019. https://doi.org/10.1155/2019/4729706. [Google Scholar] [Crossref]

21. V.P. Nguyen, H. Le Trung, T.H. Nguyen, D. Hoang, T.H. Tran, Synthesis of biogenic silver nanoparticles using Ganoderma lucidum extract and evaluation of theranostic applications, J. Nanomater. 2021. https://doi.org/10.1155/2021/6135920. [Google Scholar] [Crossref]

22. D. Sliva, Ganoderma lucidum (Reishi) in cancer treatment, Integr. Cancer Ther. 2 (2003) 358–364. https://doi.org/10.1177/1534735403259066. [Google Scholar] [Crossref]

23. H. Jiang, Y. Zhang, C. Wang, H. Wang, Recovery of hazardous microplastics through selective aluminum coating, J. Environ. Manage. 299 (2021) 113626. [Google Scholar] [Crossref]

24. M. Tawalbeh, A. Al-Othman, T. Salamah, Metal-based catalysts in pyrolysis of biomass, J. Environ. Manage. 299 (2021) 113597. [Google Scholar] [Crossref]

25. H. Yu, Y. Yang, T. Jiang, Ganoderma lucidum polysaccharide-conjugated nanoparticles for radiotherapy, ACS Appl. Mater. Interfaces. 11 (2019) 27536–27547. [Google Scholar] [Crossref]

26. V.P. Nguyen, H. Le Trung, Microwave-assisted biosynthesis of Au nanoparticles using Ganoderma lucidum, ACS Omega. 6 (2021) 32198–32207. [Google Scholar] [Crossref]

27. D. Yan, L. Li, Dioxins study in hazardous waste processing, J. Environ. Manage. 299 (2021) 113584. [Google Scholar] [Crossref]

28. M.A. Zolfagharipoor, A. Ahmadi, Agent-based groundwater modeling, J. Environ. Manage. 299 (2021) 113560. [Google Scholar] [Crossref]

29. M. Mohammadi, M. Gheibi, Bioremediation using fungal activities, J. Environ. Manage. 299 (2021) 113594. [Google Scholar] [Crossref]

30. K.S. Dunne, N.M. Holden, Phosphorus management in soils, J. Environ. Manage. 299 (2021) 113665. [Google Scholar] [Crossref]

31. A.P. Yunus, Y. Masago, Suspended solids analysis using MODIS imagery, J. Environ. Manage. 299 (2021) 113550. [Google Scholar] [Crossref]

32. M.A. Desai, A.S. Vedpathak, Electrochemical conversion studies, J. Environ. Manage. 299 (2021) 113564. [Google Scholar] [Crossref]

33. S. Sangkham, Detection of SARS-CoV-2 RNA in wastewater, J. Environ. Manage. 299 (2021) 113563. [Google Scholar] [Crossref]

34. D. Elumalai, T.Y. Suman, Gold nanoparticles using Ganoderma lucidum, Bull. Mater. Sci. 44 (2021). [Google Scholar] [Crossref]

35. Z. Tan, M.A. Koondhar, Air quality and energy consumption study, J. Environ. Manage. 299 (2021) 113572. [Google Scholar] [Crossref]

36. S. Wachtel-Galor, B. Tomlinson, Ganoderma lucidum biomarker responses, Br. J. Nutr. 91 (2004) 263–269. [Google Scholar] [Crossref]

37. C.R. Soccol, L.Y. Bissoqui, Pharmacological properties of Ganoderma lucidum spores, Int. J. Med. Mushrooms. 18 (2016) 757–767. [Google Scholar] [Crossref]

38. I.L. Tsai, C.Y. Tsai, PLGA nanoparticles with Lingzhi extracts, Exp. Eye Res. 206 (2021) 108539. [Google Scholar] [Crossref]

39. K.S. Bishop, C.H.J. Kao, Nutraceutical developments of Ganoderma lucidum, Phytochemistry. 114 (2015) 56–65. [Google Scholar] [Crossref]

40. T. Yang, F. Li, Pollutant emissions in cattle breeding, J. Environ. Manage. 299 (2021) 113615. [Google Scholar] [Crossref]

41. C. Wan, H. Li, Dicamba degradation using biochar, J. Environ. Manage. 299 (2021) 113602. [Google Scholar] [Crossref]

42. T. Söderqvist, S. Cole, Environmental compensation metrics, J. Environ. Manage. 299 (2021) 113622. [Google Scholar] [Crossref]

43. J. Wu, Z. Jiang, Microplastic contamination in water, J. Environ. Manage. 299 (2021) 113667. [Google Scholar] [Crossref]

44. X. Li, Y. Hou, Drug safety molecular design, J. Environ. Manage. 299 (2021) 113628. [Google Scholar] [Crossref]

45. F.N. Maluin, M.Z. Hussein, Chitosan nanoparticle fungicide system, Molecules. 24 (2019). [Google Scholar] [Crossref]

46. X. Lai, Y. Han, Platinum clusters using Ganoderma lucidum polysaccharide, Molecules. 26 (2021). [Google Scholar] [Crossref]

47. I.F. Mustafa, M.Z. Hussein, Hexaconazole nanodelivery system, Molecules. 26 (2021). [Google Scholar] [Crossref]

48. S. Zhang, W. Hu, Land supply-demand mismatch study, J. Environ. Manage. 299 (2021) 113605. [Google Scholar] [Crossref]

49. D. Skrzypczak, K. Mikula, Agricultural waste valorization, J. Environ. Manage. 299 (2021) 113480. [Google Scholar] [Crossref]

50. Q. Peng, R. Yang, Biodiversity conflict risk study, J. Environ. Manage. 299 (2021) 113449. [Google Scholar] [Crossref]

51. H. Kiriyama, H. Matsuda, Nitrogen stock in agriculture, J. Environ. Manage. 299 (2021) 113438. [Google Scholar] [Crossref]

52. Q. Huang, L. Li, Ganoderma polysaccharides immune enhancement, Nutrients. 11 (2019). [Google Scholar] [Crossref]

53. S. Heshmati, P. Makhdoumi, Microplastics in fish digestive system, J. Environ. Manage. 299 (2021) 113620. [Google Scholar] [Crossref]

54. Y.M. Dai, Y.Y. Li, Catalysts for biodiesel production, J. Environ. Manage. 299 (2021) 113592. [Google Scholar] [Crossref]

55. R. Kumar, A. Najda, Fungicide-loaded nanoparticles study, Polymers. 14 (2022). [Google Scholar] [Crossref]

56. C. Deng, D. Zhu, Water service supply-demand analysis, J. Environ. Manage. 299 (2021) 113660. [Google Scholar] [Crossref]

57. Z. Wang, T. Wu, Recycling electroplating sludge catalysts, J. Environ. Manage. 299 (2021) 113567. [Google Scholar] [Crossref]

58. X. Zhou, J. Lin, Ganodermataceae pharmacological functions, Am. J. Chin. Med. 35 (2007) 559–574. [Google Scholar] [Crossref]

59. J.W.M. Yuen, M.D.I. Gohel, Anticancer effects of Ganoderma lucidum, Nutr. Cancer. 53 (2005) 11–17. [Google Scholar] [Crossref]

60. S. Singh, K. Kuca, Nanoparticle effects on Ganoderma growth, Mycobiology. 48 (2020) 383–391. [Google Scholar] [Crossref]

61. D. Philip, Biosynthesis of nanoparticles using mushroom extract, Spectrochim. Acta. 73 (2009) 374–381. [Google Scholar] [Crossref]

62. Z. Molnár, V. Bódai, Green synthesis of gold nanoparticles by fungi, (2018). [Google Scholar] [Crossref]

63. J.L. Sharma, V. Dhayal, ZnO nanoparticles using fungi, 3 Biotech. 11 (2021). [Google Scholar] [Crossref]

64. S.C. Tudu, M. Zubko, CdS nanoparticles using mushroom extract, Appl. Phys. A. 127 (2021). [Google Scholar] [Crossref]

65. A. Ahmad, P. Mukherjee, Enzyme-mediated nanoparticle synthesis, J. Am. Chem. Soc. 124 (2002) 12108–12109. [Google Scholar] [Crossref]

66. A novel DNA nanosensor based on CdSe-ZnS quantum dots and Fe₃O₄ nanoparticles. [Google Scholar] [Crossref]

67. N. Li, Y.L. Hu, Ganoderma lucidum polysaccharide nanoparticles, J. Pharm. Pharmacol. 62 (2010) 139–144. [Google Scholar] [Crossref]

68. A. Umar, S. Ahmed, Laccase characterization from Ganoderma, Sci. Rep. 12 (2022). [Google Scholar] [Crossref]

69. M. Hu, W. Deng, Activated char briquettes adsorption study, J. Environ. Manage. 299 (2021) 113601. [Google Scholar] [Crossref]

70. J. Liu, R. Liu, Risk mitigation using Bayesian networks, J. Environ. Manage. 299 (2021) 113640. [Google Scholar] [Crossref]

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