"Impact of Sub-Lethal Monosodium Glutamate Exposure on Hepatic Protein Profiles in Labeo Rohita"

This study evaluated the ecotoxicological impact of Monosodium Glutamate (MSG) on the freshwater fish Labeo rohita (Rohu). The experiment focused on alterations in liver total protein levels following chronic sub-lethal exposure. Labeo rohita were exposed to a constant sub-lethal dose of 10 mg/L of MSG across three progressive temporal intervals: 5, 10, and 15 days. A parallel control group was maintained in chemical-free freshwater. Quantitative estimation of total liver proteins was conducted using standard spectrophotometric methods.

The results demonstrated a highly significant, time-dependent decline in total liver protein concentration in all MSG-exposed groups compared to the control group. The baseline liver protein level in the control group was recorded at 65.4 ± 1.2 mg/g of wet tissue. Upon exposure to 10 mg/L of MSG, liver protein levels dropped to 52.1 ± 1.0 mg/g on Day 5, 41.8 ± 0.9 mg/g on Day 10, and reached a minimum value of 28.5 ± 0.7 mg/g on Day 15. This marked depletion highlights severe physiological stress, metabolic reallocation, and potential cellular degradation in the hepatic tissue. The study confirms that even low concentrations of agricultural or industrial MSG runoff pose a threat to aquatic organisms by disrupting essential protein synthesis pathways.

Monosodium Glutamate, Labeo rohita, Liver Protein, Ecotoxicity, Metabolic Stress.

1. Ataseven, H., et al. (2025). Evaluation of the Effects of Monosodium Glutamate on Hepatic and Renal Oxidative Stress. MDPI Toxics, 15(3), 64. [Google Scholar] [Crossref]

2. Diniz, Y. S., et al. (2021). Toxicity of monosodium glutamate intake on different tissues and metabolic profiles. Journal of Metabolic and Animal Sciences, 26(3), 45-58. [Google Scholar] [Crossref]

3. Eweka, A. O., & Om'Iniabohs, F. A. E. (2020). Histochemical Studies of the Effects of Monosodium Glutamate on the Liver of Adult Wistar Rats. Internet Journal of Gastroenterology, 12(2). [Google Scholar] [Crossref]

4. Niaz, K., et al. (2020). Monosodium glutamate induces memory and hepatic challenges in test models: Defensive role of herbal intervention. PMC Pharmacology, 11(4), 215-227. [Google Scholar] [Crossref]

5. Perumalsamy, K., et al. (2024). Histopathological alterations in the vital organs of Indian major carp Labeo rohita exposed to sub-lethal concentration of MSG. Journal of Basic and Applied Zoology, 85(10), 1-12. [Google Scholar] [Crossref]

6. Sharma, A. (2021). Changes in the plasma electrolytes of fresh water teleost fish Labeo rohita exposed to sublethal concentration of monosodium glutamate. ResearchGate Publication, 352041990. [Google Scholar] [Crossref]

7. Thomas, M., et al. (2023). The excitotoxic effect of monosodium glutamate on Zebra Fish (Danio rerio). International Journal of Biosciences, 23(6), 112-120. [Google Scholar] [Crossref]

8. Zanfirescu, A., et al. (2019). A review of the alleged health hazards of monosodium glutamate. Comprehensive Reviews in Food Science and Food Safety, 18(4), 1111-1134. [Google Scholar] [Crossref]

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